HIV protein manipulates hundreds of genes to advance progression into AIDS,...
UT Southwestern Medical Center researchers have deciphered how a small protein made by the human immunodeficiency virus (HIV) that causes AIDS manipulates human genes to further its deadly agenda.
View ArticleNewly identified receptor may help gene therapy go viral
Gene therapy, whereby a patient's disorder is treated by inserting a new gene, replacing a defective one, or disabling a harmful one, suffered a setback in 1999, when Jesse Gelsinger, an 18-year-old...
View ArticleResearchers identify way radiation may fight cancer cells escaping immune system
A team of Georgia State University researchers is fighting cancers using a combination of therapies and recently found ways that radiation could maximize responses to novel immune-based therapeutic...
View ArticleGene therapy for Parkinson's disease to be tested
Experts at the University of Pittsburgh School of Medicine are leading the second arm of a clinical trial using gene therapy to relieve the symptoms of tremor and mobility impairment in patients with...
View ArticleCan gene therapy provide a breakthrough in Alzheimer's disease?
Therapeutic gene transfer to specific brain regions in animal models of Alzheimer's disease has uncovered multiple potential treatment approaches that deserve to be considered as candidates for...
View ArticleResearchers fight aplastic anemia using a therapy designed to delay ageing
Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace. Many forms of aplastic anaemia share an...
View ArticleUpdate on advances in gene therapy from National Center for Advancing...
New initiatives by the National Center for Advancing Translational Sciences (NCATS) to use gene therapy approaches to treat rare diseases and especially promising aspects of gene transfer and gene...
View ArticleHigh-precision robotic system targets ocular surgery
Preceyes B.V., a spin-off of Eindhoven University of Technology, and Nightstar (UK) have entered into a collaboration for the development of a high-precision drug delivery technology in the eye....
View ArticleScientists use synthetic gene and magnets to alter behavior of mice, fish
University of Virginia scientists have demonstrated that neurons in the brain that have been supplemented with a synthetic gene can be remotely manipulated by a magnetic field. The finding has...
View ArticlePregnant women support first maternal gene therapy trial
Pregnant women would be willing to trial maternal growth factor gene therapy to treat severe early-onset fetal growth restriction (FGR) in their unborn babies, according to a new study. If the proposed...
View ArticleScientists engineer immune cells to protect organs from transplant rejection
Scientists at BC Children's Hospital and the University of British Columbia have developed a gene therapy that programs a type of immune cell called T regulatory cells (Tregs) to protect transplanted...
View ArticlePromising results reported in study of AAV-based gene delivery to treat...
A new study in patients with the inherited metabolic disorder methylmalonic academia (MMA) found lower than expected levels of antibodies against the adeno-associated viral (AAV) vectors being...
View ArticleHidden genetic mutations in stem cells could undermine therapeutic benefit
For the first time, scientists have confirmed the long-standing hypothesis that as people age, they accumulate gene mutations in their mitochondria—cells' energy source.
View ArticleNewly identified host defense mechanism protects cells from viral infection
A new study to understand why viral particles tend to accumulate in a specific location around a cell's nucleus in the first several hours after viral infection has shown this phenomenon to be a novel...
View ArticleGene therapy shows early success against 'Bubble Boy' disease
Adolescents and young adults with a severe inherited immunodeficiency disorder improved following treatment with novel gene therapy developed at St. Jude Children's Research Hospital and at the...
View ArticleGene therapy shows long-term benefit for treating rare blindness
Pioneering gene therapy has restored some vision to patients with a rare form of genetic blindness for as long as four years, raising hopes it could be used to cure common causes of vision loss, new...
View ArticleGene therapy halts pulmonary hypertension progression in large animal...
Scientists have used a novel gene therapy to halt the progression of pulmonary hypertension, a form of high blood pressure in the lung blood vessels that is linked to heart failure, according to a...
View ArticleGene replacement therapy offers viable treatment option for fatal disease
Spinal muscular atrophy (SMA) is a disease that causes progressive degeneration in the nerve cells that control muscles, thereby causing muscle weakness and eventually death. SMA affects approximately...
View ArticleResearch findings reveal potential to reverse cancer-related nerve pain
A study providing new information about neuropathic pain afflicting some 90 percent of cancer patients who have had nerve damage caused by tumors, surgery, chemotherapy or radiation indicates gene...
View ArticleProgress and promise of gene transfer and gene editing to cure beta-thalassemias
Promising results from the first clinical trials of globin gene transfer to treat beta-thalassemias-inherited forms of anemia-have eliminated the need for blood transfusions in some individuals....
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