While target therapies directed toward genetic mutations that drive a tumor's growth have significantly improved the outlook for many patients, they have not been as successful in controlling brain metastases in several types of cancer. In the case of breast cancer driven by overexpression of the HER2 gene, up to 50 percent of patients treated with targeted therapies eventually develop brain metastases, which are inevitably fatal. Now a Massachusetts General Hospital (MGH)-based research team has identified a novel mechanism behind the resistance to HER2- or PI3K-targeted therapies and a treatment strategy that may overcome this resistance.
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