The hypothesis that memory T cells formed in response to childhood infections may be to blame for the loss of expression of therapeutic genes delivered via viral vectors has been hotly debated, but recent clinical trials of adeno-associated viral (AAV) vector-based gene therapies designed specifically to avoid T-cell responses to AAV have shown the ability to correct debilitating diseases such as hemophilia in some patients. The scientists who proposed this hypothesis discuss the ongoing controversy and progress in developing approaches to overcome AAV-vector-induced T cell responses in an article in Human Gene Therapy.
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